PRIME: A Multi-Agent Environment for Orchestrating Dynamic Computational Workflows in Protein Engineering

Y Zhou, J Su, J Zhang, W Hu, T Tao, G Li, X Zhou , L Fan, F Yuan

Published in bioRxiv, 2025

Multi-agent system orchestrating dynamic computational workflows from 65+ protein engineering tools.

PRIME addresses the fragmentation and technical complexity that hinder practical application of AI in protein engineering. The system interprets high-level engineering objectives and autonomously constructs custom computational pathways by reasoning over a library of more than 65 validated protein tools. By grounding every step in verifiable tool execution, PRIME mitigates hallucination risks from general-purpose AI agents.

Citation

Y Zhou, J Su, J Zhang, W Hu, T Tao, G Li, X Zhou, L Fan, F Yuan. (2025). "PRIME: A Multi-Agent Environment for Orchestrating Dynamic Computational Workflows in Protein Engineering." bioRxiv.